| Autor: |
Wesslén, Tore, Hermodsson, Svante, Philipson, Lennart |
| Zdroj: |
Archiv für die Gesamte Virusforschung; 1959, Vol. 9 Issue 1, p31-44, 14p |
| Abstrakt: |
In preliminary experiments it was shown that cells in monolayers of monkey kidney cultures can be protected from the cytopathogenic effect of poliomyelitis virus types 1, 2 and 3, some ECHO and Coxsackie viruses if influenza virus is added to the culture some days before the introduction of the challenge virus. The interference between influenza and poliomyelitis virus was then studied in detail. About 25% of the cells were degenerated by influenza virus alone. Most of the residual cells were protected against the degenerative effect of poliomyelitis virus when large amounts of influenza virus had been inoculated 48 hours before. If the interval between the virus inoculations was 12 hours only a small number of surviving cells were found. All cells degenerated when both viruses were inoculated simultaneously. No significant reduction in the yield of poliomyelitis virus was recorded when both viruses were inoculated simultaneously or when the interval between the two inoculations was less than 12 hours. With an interval of 12 hours the yield was reduced by 90%, and an interval of 72 hours resulted in a decrease of about 3 powers of ten in the propagation of poliomyelitis virus. Inoculation of influenza virus inactivated by heat or ultra-violet irradiation did not produce interference or cell protection. Impairment of the adsorption of the challenge virus was found not to be involved in the mechanism of the interference. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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