The acute effect of sertindole on brain 5-HT, D and α receptors (ex vivo radioreceptor binding studies).

Autor:	Hyttel, J., Nielsen, J., Nowak, G.
Zdroj:	Journal of Neural Transmission; 1992, Vol. 89 Issue 1/2, p61-69, 9p
Abstrakt:	The ability of sertindole to influence the ex vivo binding ofH-ketanserin,H-prazosin andH-spiperone to 5-HT receptors, α-adrenoceptors and DA D receptors, respectively, in rat brain has been studied after acute treatment. Sertindole is a potent, long acting compound which readily passes the blood-brain barrier. It dose-dependently binds to all three receptors types. In line with in vivo behavioural experiments sertindole has the most pronounced effect on 5-HT receptors, lower effect on α-adrenoceptors and the lowest effect on striatal D receptors. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink