A convenient method for C-labeling of 2-methylthio-1-[4-N-α-ethoxycarbonylbenzyl)-amino-benzyl]-5-hydroxymethyl-2-[C]-1H-imidazole and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-2-[C]-1H-imidazole as potential antihypertensives

Autor:	Saemian, Nader, Shirvani, Gholamhossein, Oliyaee, Sayed, Javaheri, Mohsen
Předmět:	RADIOLABELING IMIDAZOLES CHEMICAL synthesis INTERMEDIATES (Chemistry) RADIOCARBON dating ANGIOTENSIN-receptor blockers THIOCYANATES
Zdroj:	Journal of Radioanalytical & Nuclear Chemistry; Apr2012, Vol. 292 Issue 1, p237-241, 5p, 3 Diagrams
Abstrakt:	The key synthetic intermediate, (2-mercapto-1-(4-nitrobenzyl)-1H-imidazol-5-yl)methanol-[2-C], has been synthesized by using one pot procedure from potassium[C]-thiocyanate. It was converted to two nonpeptide angiotensin II receptor antagonists, 2-methylthio-1-[4-N-α-ethoxycarbonyl benzyl)-aminobenzyl]-5-hydroxymethyl-1H-imidazole-[2-C] and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-1H-imidazole-[2-C] via a 3-step sequence synthetic pathway. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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