| Autor: |
Nissen, Catherine, Moser, Yolanda, Weis, Johanna, Würsch, Andreas, Gratwohl, Alois, Speck, Bruno |
| Zdroj: |
Blut: Zeitschrift für die Gesamte Blutforschung; 1986, Vol. 52 Issue 4, p221-230, 10p |
| Abstrakt: |
Peripheral blood cells from patients with aplastic anemia were tested for their ability to release interleukin-2 (IL-2) and colony stimulating activity (CSA) before treatment. IL-2 release - as measured in the mouse thymocyte assay - was abnormally high in 18/34, and abnormally low in 10/34 patients. 'Low' release was due to simultaneous release of thymocyte inhibitors. In 18 patients who achieved self-sustaining hemopoiesis after high dose immunosuppressive therapy, excess IL-2 release decreased to low levels ( p<0.001), and the release of inhibitors disappeared. In contrast, the release of CSA by patient cells - which did not correlate with peripheral blood monocyte counts - either remained high or increased to excessively high values in 24/24 patients tested before and after successful immunosuppressive treatment. Patients with stable hemopoietic grafts after bone marrow transplantation for aplastic anemia, did not release excess CSA. It is concluded that IL-2 and CSA play opposite roles in aplastic anemia. High IL-2 release seems associated with disease activity, whereas high CSA-release appears to reflect a repair mechanism. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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