| Autor: |
DeLuca, H., Holick, S., Holick, M. |
| Zdroj: |
Calcified Tissue Research; 1975, Vol. 21 Issue 1, p128-135, 8p |
| Abstrakt: |
High activity [6-H]-1α-hydroxyvitamin D has been chemically synthesized and shown to be converted rapidly to 1,25-dihydroxyvitamin D in both rats and chicks. This rapid conversion takes place prior to initiation of intestinal calcium transport which suggests that 1α-hydroxyvitamin D must be converted to 1,25-dihydroxy-vitamin D before it functions, although direct action of 1α-hydroxyvitamin D cannot be totally excluded. The conversion of 1α-hydroxyvitamin D takes place in the liver and not intestine of the rat. On the other hand, both liver and intestine of chicks can carry out this conversion. The 1α-hydroxyvitamin D rapidly disappears from blood and intestine of rats being essentially absent 12 hours after a 325 pmole dose, while the formed 1,25-dihydroxyvitamin D persists much longer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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