Urinary β-1-galactosyl-0-hydroxylysine (GH) as a marker of collagen turnover of bone.

Autor: Moro, Luigi, Mucelli, Roberto, Gazzarrini, Carlo, Modricky, Chiara, Marotti, Francesco, Bernard, Benedetto
Zdroj: Calcified Tissue International; 1988, Vol. 42 Issue 2, p87-90, 4p
Abstrakt: β-1-galactosyl-0-hydroxylysine (GH) was measured in the urine of 59 women and 48 men, aged 30-79 years, by High Performance Liquid Chromatography (HPLC) of the dansylated derivative. Vertebral mineral density, measured by quantitative computed tomography (QCT), and urinary GH were inversely correlated (r=−0.74; P<0.001). High rate of bone mineral loss is associated with a high urinary GH excretion. Measurement of GH in urine provides a simple and noninvasive method for the evaluation of the extent of bone resorption in large groups of subjects and appears to be more specific than urinary hydroxyproline excretion. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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