| Abstrakt: |
Bones of 4-week-old Sprague-Dawley rats fed a diet containing 0.25% β-aminoproprionitrile ( β-APN) for 21 days and injected withH-proline,H-tetracycline, and cold tetracycline at 5-, 10-, and 20-day intervals were analyzed for incorporation ofH-proline andH-tetracycline. Tibial cross sections were examined by fluorescent microscopy to determine the linear bone apposition between intervals and the distribution and intensity of tetracycline bands. The incorporation ofH-proline was similar in β-APN-treated and control rats. Incorporation ofH-tetracycline, however, was significantly lower in β-APN-treated rats. Fluorescent microscopy of tibial cross sections showed a comparable amount of linear matrix apposition in control and treated rats. It is suggested that β-APN does not inhibit the bone matrix formation but does interfere with its mineralization. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink