| Autor: |
Marone, C., Reubi, F., Perisic, M., Lahn, W. |
| Zdroj: |
European Journal of Clinical Pharmacology; 1984, Vol. 27 Issue 5, p589-593, 5p |
| Abstrakt: |
The pharmacokinetics of piretanide was studied in 10 patients with chronic renal failure. After administration of a high oral dose (12 to 192 mg) of piretanide the kinetics behaved according to an open 2-compartment model. The elimination constant in the first phase (α) ranged from 0.385 to 0.756 h and in the second phase ( β) from 0.079 to 0.274 h. The corresponding elimination half-lives ranged from 55 to 108 min (t α) and from 152 to 524 min (t β). Only an average of 2.8% of the orally administered drug was recovered in 24 h urines. Nevertheless, a good correlation was found between urinary recovery or renal clearance of the drug and residual renal function. The elimination of piretanide by non-renal mechanisms appeared to be increased when renal function was greatly diminished. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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