| Autor: |
Larochelle, P., Hamet, P., Beroniade, V., Kuchel, O. |
| Zdroj: |
European Journal of Clinical Pharmacology; 1978, Vol. 14 Issue 1, p1-5, 5p |
| Abstrakt: |
Minoxidil is a potent anti-hypertensive drug which acts on the peripheral arteriolar smooth muscle. It was administered to 14 patients with severe hypertension where standard therapy failed to control the blood pressure. The mean initial blood pressure was 209/129 when receiving treatment. Minoxidil was given in doses varying from 7.5 to 40 mg (mean = 24 mg) and was associated with propranolol (mean dose = 170 mg) and furosemide (mean dose = 120 mg). Twelve patients had an adequate therapeutic response. The systolic blood pressure was reduced by 44 mm Hg which represents a 23±3% reduction and the diastolic blood pressure was reduced by 33 mm Hg which represents a 26±3% reduction. Two patients were considered treatment failures and two patients died during Minoxidil treatment. Three patients showed electrocardiographic changes caracterized by T wave inversion at the onset of Minoxidil treatment and these changes were reversible in two. All patients except two had hirsutism and two women developped polymenorrhea. Other side effects consisted of tachycardia and weight gains. One patient with lupus erythematodes had an exacerbation of her disease while on Minoxidil. Minoxidil represents a useful and effective adjuvant to the treatment of resistant hypertension. It can delay bilateral nephrectomy in patients with terminal renal failure and high blood pressure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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