| Autor: |
Ogura, Chikara, Majima, Kazuaki, Nakasawa, Kazuyoshi, Nakamura, Ikan, Umezawa, Yoichi, Ueda, Hajime |
| Zdroj: |
European Journal of Clinical Pharmacology; 1978, Vol. 13 Issue 6, p413-418, 6p |
| Abstrakt: |
A new method, 24-hour polygraphy (EEG, EMG, and EOG), was applied not only to investigate the influence of hypnotics on night sleep, but to examine the precise influence on sleep-wake-fulness rhythm the day following administration. The hypnotics used were flurazepam 15 mg and nitrazepam 5 mg. The subjects were healthy volunteers, 5 men and 4 women, aged 20-50 years. The polygraphic record was made three times for each subject. Flurazepam prolonged sleep time (%) significantly (p<0.05), shortened sleep latency (p<0.05), decreased waking period (p<0.05), and increased the percentage of Stage 2 sleep (p<0.1) in comparison to nitrazepam. Flurazepam 15 mg appears to be a better hypnotic than nitrazepam 5 mg, but caution is required in its use because of a greater residual sedative effect on the following day. Some nondrug factors affecting sleep and a method for detecting the residual effect of hypnotics are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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