Individual differences in serum levels of lithium in human subjects receiving fixed doses of lithium carbonate. relation to renal lithium clearance and body weight.

Autor: Sedvall, Göran, Pettersson, Ulla, Fyrö, Bengt
Zdroj: Pharmacologia Clinica; 1970, Vol. 2 Issue 4, p231-235, 5p
Abstrakt: Serum levels of lithium were determined in ten healthy subjects receiving a fixed dose regimen of lithium carbonate for eight days. A steady state level of the morning serum lithium concentration was obtained after 6 to 8 days, and this level varied up to 3-fold between subjects. The lithium levels in serum were significantly correlated with the renal lithium clearances ( p<0.05). There was a highly significant correlation ( p<0.001) between the steady state level and the product of lithium clearance and body weight. No correlation was found between renal lithium and creatinine clearances. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index