| Abstrakt: |
The duration of the adrenocorticotrophic effects of two synthetic ACTH preparations was studied in healthy volunteers. One of the hormones, β corticotropin, was adsorbed on zinc; the other, a D-serine-norleucine-valinamide- β corticotropin, was thought to be more stable, owing to the replacement of the three most susceptible amino acids in the ACTH molecule. - β corticotropin, administered intramuscularly in a dose of 1 mg, showed biological activity lasting for 28 h, an effect equal to that which may be expected of depot preparations of pituitary extracts. D-serine-norleucine-valinamide- β corticotropin, administered intra muscularly in a dose of 0.16 mg, had only a weak adreno corticotrophic effect, whereas intravenously the same dose produced a greater effect that persisted for nearly 8 h. After intramuscular injection of both preparations a significant difference was found between the maximum responses shown by men and women. [ABSTRACT FROM AUTHOR] |
