Plasma-Katecholamin-Verlauf bei Alkylphosphat-Intoxikationen und deren Therapie.

Autor: Kauert, G., Schoppek, B., Clarmann, M., Hibler, A.
Zdroj: Klinische Wochenschrift; Apr1989, Vol. 67 Issue 8, p456-462, 7p
Abstrakt: In connection with the 'endogenous acetylcholine-poisoning' due to organophosphorous compounds beside the clinical important muscarinic and nicotinic symptoms an activation of the sympathetic nervous system (adrenal medulla, sympathetic ganglia) is expected. Therefore a kinetic profile of norepinephrine and epinephrine in the plasma of two patients with severe parathionpoisonings was taken up through the whole period of the intensive-medical treatment. The method used was HPLC with electrochemical detection. The parathion-concentration of the same plasma samples were measured, too. The result were individual different courses with periodically appearing, markedly increased plasma catecholamine values. A direct correlation of catecholamines with the parathion-concentration was not recognizable. A possible influence of the atropine-treatment as well as of stress-factors is discussed but estimated as not responsible for the observed peaks. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index