| Autor: |
Becher, H., Schollmeyer, P. |
| Zdroj: |
Klinische Wochenschrift; Aug1983, Vol. 61 Issue 15, p751-757, 7p |
| Abstrakt: |
The effect of 9- β-arabinofuranosyladenine 5′-monophosphate (ara-AMP) on the purine salvage pathway has been studied. On a dose-dependant basis ara-AMP inhibits the incorporation of adenine-8-C into nucleotides in intact erythrocytes. The partially purified enzymes of the purinc salvage pathway, the adenine phosphoribosyltransferase and the 5′-phosphoribosyl-1-pyrophosphate (PP-ribose-P) synthetase, but not the hypoxanthine-guanine phosphoribosyltransferase, are inhibited by ara-AMP in a non-competitive manner. The possible adverse drug interactions which might occur by the simultaneous use of ara-AMP and other antimetabolites are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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