| Autor: |
Metzner, Beatrix, Elsner, Jörn, Dobos, Gustav, Kownatzki, Eckhard, Parlow, Frauke, Schraufstätter, Ingrid, Norgauer, Johannes |
| Zdroj: |
Agents & Actions; Oct1994, Vol. 42 Issue 3/4, p101-106, 6p |
| Abstrakt: |
The neutrophil chemotaxins, complement fragment C5a (C5a) and GROα, induced the mobilization of Ca from intracellular stores and the polymerization of actin in human neutrophils as assayed by flow cytometric measurements. [Ca]-transients developed as an 'all-or-none' response. Individual neutrophils required different threshold concentrations of added ligand to induce [Ca]-transients which were then always maximal. In contrast, chemotaxin-induced formation of actin filaments in single neutrophils occurred in a dose-dependent manner. Pertussis toxin blocked chemotaxin-induced actin polymerization and [Ca]-transients indicating that both cell responses shared initial activation steps such as ligand binding and activation of guanine nucleotide-binding proteins (G-proteins). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
