| Autor: |
O'Byrne, E., Blancuzzi, V., Wilson, D., Wong, M., Peppard, J., Simke, J., Jeng, A. |
| Zdroj: |
Agents & Actions; Sep1991, Vol. 34 Issue 1/2, p46-48, 3p |
| Abstrakt: |
Intra-articular (i.a.) injection of recombinant human interleukin-1 alpha (rHuIL-1 α) in rabbit knees induced both an inflammation, as determined by increases in leukocytes in the joint fluid, and cartilage degradation, as measured by loss of proteoglycan. Substance P (SP) and prostaglandin E (PGE) levels in the joint lavage are also elevated. Treatment with 5 mg indomethacin/kg, p.o., b.i.d., 2 mg triamcinolone i.a., and 10 mg dexamethasone/kg, p.o., reduced synovial lavage leukocyte counts, as well as PGE and SP lavage concentrations induced with IL-1 injection. However, none of the treatments inhibited rHuIL-1-induced proteoglycan loss. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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