| Autor: |
O'Byrne, E., Goldberg, R., Doughty, J., Wong, M., Blancuzzi, V., Wilson, D., Jeng, A. |
| Zdroj: |
Agents & Actions; Sep1991, Vol. 34 Issue 1/2, p232-234, 3p |
| Abstrakt: |
The effect of SP on recombinant human IL-1 α-induced cartilage degradation in rabbit knees was investigated. Co-injection of 10 ng IL-1 and 1 μg SP did not increase cartilage degradation above the level observed after injection of 10 ng IL-1 alone. Co-injection of 100 ng IL-1 and 150 μg Spantide, a potent SP antagonist, did not reduce the level of cartilage degradation. Infusion of 100 ng SP/day for two weeks did not induce cartilage degradation. These observations suggest that cartilage degradation induced by IL-1 is independent of SP concentrations in rabbit knees. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
