| Autor: |
Weyer, A., Dandeu, J., Etiévant, M., Bourgeois, J., Marchand, F., Prouvost-Danon, A., David, B. |
| Zdroj: |
Agents & Actions; Apr1989, Vol. 27 Issue 1/2, p52-54, 3p |
| Abstrakt: |
FPLC purification of mouse monoclonal anti-human IgE antibody xb6-16 showed 2 major peaks of different molecular weight, peak 1 (>10 d) and peak 3 (1.6×10 d). Peak 1 consisted of IgG 1 and IgM, peak 3 of IgG 1 only. On a protein weight basis, peak 1 was 100 times more potent than peak 3 in inducing histamine release from human basophils. Preincubation of peak 3 with anti-IgG 1 enhanced the mediator release triggered by this fraction. On this basis, the potentiating effect of aggregated IgG 1 or IgG 1-IgM complexes on mediator release from basophils is discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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