| Autor: |
Kuriyama, K., Hiyama, Y., Ito, K., Yoshinaka, I., Bito, Y. |
| Zdroj: |
Agents & Actions; Sep1988, Vol. 25 Issue 3/4, p321-325, 5p |
| Abstrakt: |
The protective effects on mast cell activation were compared between a new antiallergic agent, KP-136 and disodium cromoglycate (DSCG), both of which inhibited the immunological degranulation of rat peritoneal mast cells. The IC was 0.03 μg/ml for KP-136 and 4.7 μg/ml for DSCG. KP-136 predominantly acted on the early stage of mast cell activation processes and inhibited the immunological increase inCa uptake. KP-136 also inhibited A23187-and heat-induced degranulation and heat-induced hemolysis. In addition, KP-136 was effective on phospholipase A-induced degranulation, although the compound did not directly affect the enzyme activity. In all tests for comparison, KP-136 and DSCG had similar profiles of action and the parallel experiments indicated that KP-136 was a more potent inhibitor of mast cell activation than DSCG, having a DSCG-like membrane stabilizing activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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