| Autor: |
Etienne, A., Hecquet, F., Soulard, C., Spinnewyn, B., Clostre, F., Braquet, P. |
| Zdroj: |
Agents & Actions; Jan1986, Vol. 17 Issue 3/4, p368-370, 3p |
| Abstrakt: |
The effects of BN 52021, a new specific paf-acether receptor antagonist and the total Ginkgo biloba extract (GBE 761) from which this product was isolated, were studied in the rat on paf-acether-induced permeability and cell number changes and on endotoxin-induced lethality. Their activities were compared to those of cycloxygenase, 5-lipoxygenase and phospholipase A inhibitors. BN 52021 given s.c. or orally exerted a dose-related inhibition of paf-acether deleterious effects as well as of endotoxin lethality whereas the other drugs tested were poorly effective. These results strongly suggest paf-acether involvement in endotoxic and septic shock. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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