| Autor: |
Sydbom, Anita, Terenius, Lars |
| Zdroj: |
Agents & Actions; Apr1985, Vol. 16 Issue 3/4, p269-272, 4p |
| Abstrakt: |
The basic opioid peptide dynorphin was tested for histamine-releasing activity on peritoneal rat mast cells. Dynorphin was found to induce a dose-dependent histamine release from the mast cells. The threshold concentration was 2×10 M and release was maximal (40% of total) at 2×10 M of the peptide. The dynorphin-induced histamine release was a very rapid process completed within 10 seconds at 37°C. The release was independent of extracellular calcium. Experiments with naloxone and a specific kappa-agonist (U-50,488H) gave results indicating that the dynorphin induced histamine release was probably not mediated through opioid k-receptors. A couple of other Arg-Pro containing peptides of different origin were also screened for histamine-releasing activity. Most of these peptides elicited a more or less pronounced histamine release, provided the peptide contained more than 5 amino acids, suggesting that the Arg-Pro sequence is of importance for the histamine-releasing effect of peptides such as dynorphin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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