Inhibition of plant and mammalian diamine oxidase by substrate analogues.

Autor: Biegański, Tadeusz, Osińska, Zofia, Masliński, Czesław
Zdroj: Agents & Actions; Apr1982, Vol. 12 Issue 1/2, p41-46, 6p
Abstrakt: Imidazoles, aliphatic substrate analogues and the natural dipeptides, carnosine and anserine, were investigated as inhibitors of diamine oxidase from the pig kidney, human pregnancy plasma and pea seedlings. Imidazole, methyli-midazoles, N-acetylimidazole, histamine and N-methyl-histamine are relatively potent inhibitors of mammalian diamine oxidase showing no influence on plant enzymes. Anserine and carnosine are inhibitors of pig kidney and pea seedling enzymes. K values are 2 μ M and 10 μ M respectively. Investigated natural derivatives of putrescine and cadaverine have no influence on diamine oxidase of different origin. In conclusion, we present some evidence to suggest that mammalian diamine oxidase, despite a high reaction rate with putrescine, is better adapted to histamine oxidation, whereas for plant enzymes the diamines are preferred substrates. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index