| Abstrakt: |
The histamine-releasing activity of some basic peptides was tested on mast cells from Sprague-Dawley or Brown Norway rats. Somatostatin, bombesin, vasoactive intestinal peptide (VIP) or substance P did not give any histamine release in concentrations up to 10 M. Somatostatin in 10 M concentration released 25% of total histamine. However, neurotensin induced a significant histamine release from Brown Norway mast cells at 10 M. The neurotensin-induced histamine release was found to be selective and in some aspects similar to that induced by compound 48/80. [ABSTRACT FROM AUTHOR] |
