| Autor: |
Kazimierczak, Wacław, Szczepaniak, Krystyna, Bańkowska, Katarzyna |
| Zdroj: |
Agents & Actions; Apr1981, Vol. 11 Issue 1/2, p96-98, 3p |
| Abstrakt: |
Two selective H-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells. IgE-mediated basophil histamine release was inhibited by stimulation of histamine H-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release. The results are consistent with the view that activation of adenylate cyclase via H-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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