| Autor: |
Doly, Michel, Braquet, Pierre, Droy, Marie-Thérèse, Bonhomme, Brigitte, Ruchoux, Marie-Madeleine, Meyniel, Gaston |
| Zdroj: |
Neurochemical Pathology; Feb1988, Vol. 8 Issue 1, p15-26, 12p |
| Abstrakt: |
In the first stage the authors highlight the functional impairments owing to diabetic retinopathy by performing experiments on isolated retinas of alloxan-induced diabetic rats. After 1 mo evolution of diabetes, the electroretinograms (ERG) obtained on isolated retinas had an amplitude on average 20% lower than the controls, whereas after 2 mo of diabetes, this decrease in amplitude is around 60%. In the second stage, the authors compare the electroretinograms obtained on the isolated retina of 2 mo diabetic animals, nontreated or treated per os with Ginkgo biloba extract (100 mg/kg/d): These ERG have a significantly greater amplitude ( p<0.001) in treated animals. The results are discussed in relation to the role of oxygenated free radicals in diabetic retinopathy, the production of these induced by platelet-activating factor (PAF), and the PAF antagonistic properties of Ginkgo biloba extract, which could participate in the preventive treatment of the visual functional impairments involved in diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink