| Autor: |
Fredholm, Bertil, Sydbom, Anita |
| Zdroj: |
Agents & Actions; Apr1980, Vol. 10 Issue 1/2, p145-147, 3p |
| Abstrakt: |
Adenosine potentiated anaphylactic histamine release from isolated rat mast cells in a dose-dependent manner between 10 and 10 M. Adenosine was found to be present during a normal incubation of mast cells, but the concentration was low (2×10 M). In rat plasma the concentration was 1.5×10 M. The effect of 10 M adenosine was dose-dependently inhibited by theophylline. 50% inhibition was found at 3×10 M theophylline. Cyclic nucleotide phosphodiesterase inhibition required much higher concentrations (IC∼10 M). It is suggested that some of the anti-allergic actions of theophylline (clinical concentration range: 10-10 M) does not involve cyclic nucleotides but may be due to inhibition of the effects of endogenous adenosine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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