| Autor: |
Kazimierczak, Wacław, Maśliński, Czesław |
| Zdroj: |
Agents & Actions; Dec1974, Vol. 4 Issue 5, p320-323, 4p |
| Abstrakt: |
The influence of both zinc chloride and unsaturated zinc: 8-Hydroxyquinoline (Zn: 8-HQ) complex on histamine release induced by compound 48/80 have been investigated. It was found that the inhibitory action of Zn: 8-HQ complex which is known to be unable to penetrate into the cells and acts on mast cell membrane was more pronounced than the action of zinc alone. These results suggest the membrane mechanism of zinc action. The inhibitory action of zinc depends on compound 48/80 concentration when the 2 chemicals act simultaneously but it is not dependent on 48/80 concentration when zinc was added before the liberator. Zinc potentiated the histamine releasing effect of compound 48/80 when it was added after mast cells degranulation. This effect supports the hypothesis of the ionic binding of histamine in mast cells granules. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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