Increased oxygen consumption after cardiac surgery is associated with the inflammatory response to endotoxemia.

Autor: Straaten, H., Jansen, P., velthuis, H., Beenakkers, I., Stoutenbeek, C., Deventer, S., Sturk, A., Eysman, L., Wildevuur, Ch.
Zdroj: Intensive Care Medicine; Apr1996, Vol. 22 Issue 4, p294-300, 7p
Abstrakt: Objective: The aim of this study was to determine whether the increase in post-operative oxygen consumption (ΔVO) in cardiac surgery patients in related to endotoxemia and subsequent cytokine release and whether ΔVO can be used as a parameter of post-perfusion syndrome. Design: Prospective study. Setting: Operating room and intensive care unit of a university hospital. Patients: Twenty-one consecutive male patients undergoing elective coronary artery bypass surgery without major organ dysfunction and not receiving corticosteroids. Measurements and results: Plasma levels of endotoxin, tumor necrosis factor (TNF) and interleukin-6 (IL-6) were measured before, during and for 18 h after cardiac surgery. Oxygen consumption, haemodynamics, the use of IV fluids and dopamine, body temperature and the time of extubation were also measured. Measurements from patients with high ΔVO (≥median value of the entire group) were compared with measurements from patients with low ΔVO (
Databáze: Complementary Index
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