Preliminary observations on the neuromuscular abnormalities in patients with organ failure and sepsis.

Autor:	Coakley, J., Nagendran, K., Honavar, M., Hinds, C., Coakley, J H, Hinds, C J
Předmět:	DIAGNOSIS of bacterial diseases NEUROMUSCULAR disease diagnosis APACHE (Disease classification system) BACTERIAL diseases BIOPSY CATASTROPHIC illness COMPARATIVE studies ELECTROMYOGRAPHY LONGITUDINAL method RESEARCH methodology MEDICAL cooperation MULTIPLE organ failure MUSCLES NEURAL conduction NEUROMUSCULAR diseases RESEARCH EVALUATION research DISEASE incidence SEVERITY of illness index DIAGNOSIS
Zdroj:	Intensive Care Medicine; Jun1993, Vol. 19 Issue 6, p323-328, 6p
Abstrakt:	Objective: To estimate the incidence and nature of neuromuscular abnormalities in a representative group of ITU patients.Design: Prospective sequential study.Setting: Teaching hospital ITU.Patients: 23 patients who eventually stayed > 7 days on ITU who had no contraindication to muscle biopsy and whose relatives gave informed consent.Measurements and Results: Muscle histopathology, neurophysiological studies, record of all drugs administered, APACHE II score, organ system failure score, presence or absence of sepsis, clinical evaluation of neuromuscular problems, time to hospital discharge. Heterogeneous neuromuscular abnormalities were present in 22 out of 23 patients studied and included axonal neuropathy, denervation, generalised fibre atrophy, non-specific myopathy and necrotising myopathy.Conclusion: Neuromuscular abnormalities are almost invariable in longstay intensive care patients and the resulting weakness may seriously delay hospital discharge. Various abnormalities were seen but no obvious aetiological factors were identified. The origin of the abnormalities is probably multifactorial. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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