| Autor: |
Kitagawa, Motoji, Hayakawa, Tetsuo, Kondo, Takaharu, Shibata, Tokimune, Sakai, Yuzo, Sobajima, Hiroshi, Ishiguro, Hiroshi, Tanikawa, Makoto, Nakae, Yasuyuki, Kameya, Saeko, Noda, Aiji |
| Zdroj: |
International Journal of Pancreatology; Nov1991, Vol. 10 Issue 3/4, p279-286, 8p |
| Abstrakt: |
To evaluate the organ specificity of pancreatic phospholipase A (PLA) and the diagnostic value of the elevation of serum PLA levels in patients with serious diseases not involving the pancreas, we studied the organ distribution of PLA in autopsy specimens and serum level of PLA in patients who required admission to an intensive care unit (ICU). PLA was measured by a specific radioimmunoassay (RIA), using monoclonal antibody against human pancreatic PLA. Organ distribution of PLA revealed that the pancreas showed a much higher content of pancreatic PLA immunoreactivity than any other organ. An abnormally high value of serum PLA was observed in 18 of 30 patients (60%) at ICU. Both serum PLA and pancreatic isoamylase were elevated in 11 patients (37%). Of 11 patients with hyperphospholipasemia and hyperamylasemia, serum creatinine was elevated in five patients and blood urea nitrogen in nine patients. Serum PLA levels did not always rise comparably to serum creatinine and blood urea nitrogen levels. Serum PLA values showed the best correlation with serum lactate dehydrogenase levels among routine blood-chemistry tests. The elevation of serum PLA was ascribable to renal dysfunction or ischemic pancreatic damage secondary to circulatory collapse with multiple organ failure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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