| Abstrakt: |
Intravenous administration of 5 mg of hexadimethrine bromide (Polybren®) produces severe ischaemic alterations accompanied by permeability changes in the rat adrenal cortex as a partial manifestation of disseminated intravascular coagulopathy. In the vicinity of ischemic necroses many adrenocortical cells contain so-called protein-containing vacuoles (PCV) and hyaline droplets (HD). Ultrastructurally, these formations are bounded by a single limiting membrane and their contents gradually change from light, electron translucent ones in the PCV to electron dense ones in the HD. Both formations frequently contain blood cells, some of which show structural damage of various degree. Rarely, cytoplasmic fragments of adrenocortical cells were also found in the PCV and HD contents. Initially, the PCV are acid phosphatase negative, but with the progressing transformation into HD an increasing activity of acid phosphatase, probably mediated by preexisting lysosomes, can be demonstrated by electron microscopic cytochemistry. Most of the PCV and HD occurring in the present experiment can be regarded, with respect to the origin of their contents, as heterophagosomes. They appear to develop by a mechanism morphologically corresponding to endocytosis, and they gradually change into heterolysosomes. The participation of cellular autophagy remains uncertain. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink