| Autor: |
Albani, Diego, Tettamanti, Mauro, Batelli, Sara, Polito, Letizia, Dusi, Sabrina, Ateri, Eleonora, Forloni, Gianluigi, Lucca, Ugo |
| Předmět: |
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| Zdroj: |
Age; Apr2012, Vol. 34 Issue 2, p519-526, 8p |
| Abstrakt: |
The association among single nucleotide polymorphisms in inflammatory genes as interleukin-1 alpha ( IL-1α), interleukin-1 beta ( IL-1β) or tumor necrosis factor alpha ( TNF-α) and dementia has been explored mostly in Alzheimer's disease, while few data addressing their association with dementia in very old people are available. We performed a prospective, door-to-door population-based study of 80 years or older residents in eight municipalities of Varese province, Italy (the Monzino 80-plus study). No difference was found by a cross-sectional approach comparing IL-1α rs1800587, IL-1β rs3087258 and TNF-α rs1799724 genotypic and allelic frequencies between those affected and not affected by dementia. After a 5-year follow-up, the elderly carriers of T-allele of TNF-α rs1799724 were at an increased risk of dementia ( p = 0.03). This association was no more significant adjusting for the apolipoprotein E epsilon-4 allele ( APOE-ε4, p = 0.26), which was an independent predictor of dementia onset ( p = 0.0002). In short, in this Italian population of oldest olds, dementia was associated to the APOE-ε4 allele only. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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