| Autor: |
Necheles, H., Kroll, H., Bralow, S., Spellberg, M., Weiss, B., Kushino, K. |
| Zdroj: |
American Journal of Digestive Diseases; Jan1951, Vol. 18 Issue 1, p1-7, 7p |
| Abstrakt: |
The use of sodium carboxymethylcellulose, having one sodium carboxymethyl group per glucose unit, has been investigated as an antacid for the therapy of hyperacidity and peptic ulcer. Studies on normal subjects, on patients, in vitro studies, assays on gastrostomy dogs, and on dogs with histamine beeswax ulcer were performed. Accessory studies were done on guinea pigs and rats. The results indicate that sodium carhoxymethylcellulose is an efficient neutralizer of gastric acidity, that it protects dogs against histamine beeswax ulcer, and that it does not constipate, but acts as a bulk laxative. It functions chiefly as a non-systemic buffer in neutralizing gastric secretions. It has the property to stick to the gastric and duodenal mucosa and form a viscid, protective coating. It retains antacids like carbonates or magnesium oxide, and spasmolytic drugs, for prolonged periods of time in contact with the gastric and duodenal mucosa, and makes these adjuvants more effective than if thev were given alone. The complete bibliography will appear with the next paper of this series. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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