| Autor: |
Snapper, I., Saltzman, A., Greenspan, G. |
| Zdroj: |
American Journal of Digestive Diseases; Nov1946, Vol. 13 Issue 11, p341-344, 4p |
| Abstrakt: |
After ingestion of 5 grams of benzoic acid by patients with liver cirrhosis or hepatitis the glucuronate reactions are always positive in the second 2 hours' urine specimen, usually also in the first and third 2 hours' specimen. This glucuronate excretion is a sensitive liver function test. If after ingestion of 5 grams of benzoic acid, none of the three two-hours' specimens shows a positive glucuronate reaction, serious liver damage as accompanies hepatitis or cirrhosis is not present. The increased glucuronate excretion after ingestion of benzoic acid by patients with a damaged liver depends on the impairment of the hippuric acid synthesis in the damaged liver. This leads to the presence of large quantities of free benzoate in the damaged liver which is conjugated with glucuronic acid. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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