Enterochromaffin cells of the mammalian small intestine as the source of motilin.

Autor: Pearse, A., Polak, Julia, Bloom, S., Adams, Caroline, Dryburgh, Jill, Brown, J.
Zdroj: Virchows Archiv B Cell Pathology; Dec1974, Vol. 16 Issue 1, p111-120, 10p
Abstrakt: The enterochromaffin (EC) cells, present throughout the whole length of the gastrointestinal mucosa, are known to be responsible for the production of 5-hydroxytryptamine. The EC cells of the mammalian small intestine have now been shown to contain, and presumably therefore to synthesize, store and secrete, the 22-amino acid peptide motilin. This presumptive hormone cannot be found in the EC cells of stomach or colon. The morphological, physiological and pathological implications of these observations are far-reaching. At all events, the EC cells of the small intestine can now take their place as full members of the APUD series of endocrine polypeptide cells. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index