| Abstrakt: |
Treatment of rats with the anorectic drug chlorphentermine or with the tricyclic antidepressants iprindole, 1-chlor-amitriptyline, clomipramine and imipramine induced cellular lesions in retinal pigment epithelial cells and in retinal ganglion cells. The ultrastructural findings, which are characterized by the formation of numerous membrane-bound cytoplasmic inclusions with crystalloid or lamellar internal patterns, are interpreted as a manifestation of a drug-induced phospholipidosis. [ABSTRACT FROM AUTHOR] |
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