| Autor: |
Karkar, Kameel M., Garcia, Paul A., Bateman, Lisa M., Smyth, Matthew D., Barbaro, Nicholas M., Berger, Mitchel |
| Předmět: |
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| Zdroj: |
Epilepsia (Series 4); Aug2002, Vol. 43 Issue 8, p932-935, 4p |
| Abstrakt: |
Summary: Purpose: Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans. Methods: Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed. Results: Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline. Conclusions: In this patient with tumor-related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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