| Autor: |
Cherneva, Zheyna Vlaeva, Denchev, Stefan Veselinov, Gospodinova, Mariana Vasileva, Cakova, Adelina, Cherneva, Radostina Vlaeva |
| Předmět: |
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| Zdroj: |
Acute Cardiac Care; Mar2012, Vol. 14 Issue 1, p13-19, 7p, 8 Charts |
| Abstrakt: |
Background: The clinical significance of inflammatory cytokines as independent prognostic markers in patients with acute coronary syndrome (ACS) and hyperglycaemia remains uncertain. Aim: To determine the value of inflammatory biomarkers as independent prognostic indicators and their relation with hyperglycaemia in ACS patients. Methods: TNF-α and hsCRP were defined 48 h after admission and indicators for hyperglycaemia were calculated in 256 consecutive patients with ACS. A correlation analysis with standard clinical variables-EF, maximum CK, CK-MB, troponin and different indices for hyperglycaemia was performed. Patients were followed up for 12 months. Results: Baseline TNF-α correlated neither to EF, nor to the enzymes for myocardial necrosis ( P> 0.05). In contrast, hsCRP correlated negatively with EF ( P== 0.001) and positively with maximum CK, CK-MB, troponin ( P== 0.0001) irrespectively of the glucose status. TNF-α was associated with fasting glycaemia, HGI and TAG ( P== 0.033/0.041/0.018) and hsCRP-with indicators for acute, persistent and chronic glycaemia in all patients. Moreover, hsCRP was an independent marker for six-month survival ( P== 0.024). TAG was a stronger six-month survival predictor than hsCRP ( P== 0.010/0.024). Conclusion: hsCRP and TNF-α have clinical significance regardless of the glucose metabolic status. hsCRP is an independent marker for six-month survival. TAG is the better predictor for poor outcome than hsCRP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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