Contribution of H Spectroscopy to a Brief Cognitive-Functional Test Battery for the Diagnosis of Mild Alzheimer's Disease.

Autor:	Silveira de Souza, Andrea, de Oliveira-Souza, Ricardo, Moll, Jorge, Tovar-Moll, Fernanda, Andreiuolo, Pedro Angelo, Bottino, Cássio M.C.
Předmět:	ALZHEIMER'S disease diagnosis MAGNETIC resonance imaging SPECTRUM analysis ANALYSIS of covariance CHI-squared test COGNITIVE testing STATISTICAL correlation MULTIVARIATE analysis RESEARCH funding STATISTICS DATA analysis DATA analysis software
Zdroj:	Dementia & Geriatric Cognitive Disorders; 2011, Vol. 32 Issue 5, p351-361, 11p
Abstrakt:	Background/Aims: The diagnosis of mild or questionable Alzheimer's disease (AD) depends on clinical criteria that often leave a margin for doubt. We aim to verify the diagnostic accuracy of amnestic mild cognitive impairment (aMCI) and AD with proton spectroscopy (1H-MRS) combined with brief cognitive-functional scales. Methods: The relationship between 1H-MRS of the posterior cingulate cortex and the cognitive performance in Mini Mental State Examination, Blessed-Roth Dementia Rating and Functional Assessment Staging of Alzheimer Disease scales were investigated in 25 AD, 10 aMCI and 33 normal control (NC) individuals. Results: The N-acetylaspartate (NAA)/creatine and myoinositol/NAA ratios distinguished AD patients from NC (p < 0.005), and added value in diagnostic accuracy and specificity by discriminant function analysis when combined to clinical diagnosis and simple neuropsychiatric scales; an increase of 3.7% (for aMCI patients) and of 5% (for AD individuals) was observed in diagnostic accuracy, and one of 5.5% (aMCI) and of 11.1% (AD) in specificity. Conclusion:1H-MRS combined with brief cognitive-functional scales provided maximum diagnostic accuracy of AD patients, and can be useful when subtle cognitive and memory dysfunction is present. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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