| Autor: |
Kohler, Hans P., Ariëns, Robert A. S., Catto, Andrew J., Carter, Angela M., Miller, George J., Cooper, Jackie A., Mansfield, Michael W., Standeven, Kristina F., Grant, Peter J. |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Sep2002, Vol. 118 Issue 3, p825-832, 8p |
| Abstrakt: |
Summary. There is growing evidence for a role of factor XIII (FXIII) in vascular disease. FXIII measures were determined in (i) a nested case–control study from the Second Northwick Park Heart Study of 63 men with myocardial infarction (MI) and 124 age-matched controls and (ii) in a case–control study of 475 subjects with acute stroke and 461 controls followed up for 54 months for mortality. In both studies, measures of FXIII A- and B-subunit antigen, FXIII activity and prothrombin fragments (F1 + 2) were made. An in vitro model was used to investigate the effects of thrombin activity on FXIII A- and B-subunit antigen levels. In study 1, patients clinically free of coronary artery disease who later developed MI had lower adjusted FXIII A-subunit levels at recruitment (129·2%vs 113·3%, P = 0·007). In study 2, stroke patients with large vessel disease had lower A-subunit antigen levels (102·1%vs 127·2%, P < 0·001), but higher F1 + 2 levels (0·941%vs 0·753%, P < 0·05), than subjects with small vessel disease. Levels of FXIII A-subunit (100%vs 117%, P < 0·0001) were lower and F1 + 2 higher (1·020%vs 0·702%, P < 0·0001) in stroke patients who had died compared with those still alive at the end of the follow-up period. Low concentrations of FXIII A-subunit antigen predicted vascular outcome in otherwise healthy subjects and relate to both size of infarct and poor post-stroke survival in patients with acute ischaemic stroke. Low in vitro concentrations of FXIII A-subunit antigen wererelated to increased thrombin generation and, thus, increased risk of thrombotic events. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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