Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, H NMR and molecular dynamics simulation.

Autor: Lecouvey, Marc, Frochot, Céline, Miclo, Laurent, Orlewski, Piotr, Marraud, Michel, Gaillard, Jean-Luc, Thong Cung, Manh, Vanderesse, Régis
Zdroj: Letters in Peptide Science; Dec1997, Vol. 4 Issue 4-6, p359-364, 6p
Abstrakt: The conformation of a benzodiazepine-like decapeptide corresponding tothe YLGYLEQLLR fragment of a casein has been examined in a sodium dodecylsulfate micellar medium using circular dichroism, two-dimensionalH NMR spectroscopy and restrained molecular dynamicssimulation. The decapeptide adopts an amphipathic 3-helicoidstructure in which theE···R ionic bridgestabilizes the C-terminus. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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