| Autor: |
Shibata, Kenji, Yano, Keiichi, Tanaka, Takeo, Matsuda, Yuzuru, Yamasaki, Motoo |
| Zdroj: |
Letters in Peptide Science; Jun1997, Vol. 4 Issue 3, p167-170, 4p |
| Abstrakt: |
RES-701-1 is an endothelin B receptor (ET) selective peptidic antagonist, which has a novel cyclic structure of microbial origin. Modification at the C-terminal free carboxyl group of RES-701-1 by a methyl ester results in an ET/ET dual selective analog, which showed relatively high affinity for ET receptor subtype, while retaining the affinity for ET. The carboxyl-group-deleted analog with tryptamine as the C-terminal residue also showed relatively weak affinity for ET; however, benzyl ester or amide analogs did not show remarkable affinity for ET. It is suggested that the binding mode of RES-701-1 and its analogs is different from those of known ligands for ET receptors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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