Immunological aspects of urate oxidase therapy in hyperuricaemia.

Autor: Fitzpatrick, D., FitzGerald, O., McGeeney, K.
Zdroj: Irish Journal of Medical Science; Dec1977, Vol. 146 Issue 1, p155-161, 7p
Abstrakt: The immunological relationship between urate oxidase (uricase) prepared from microbiological and animal sources was studied. The enzymes from these two groups were found to be immunologically unrelated. Within each group cross reaction did occur; cross reactivity was frequent among the enzymes from animal sources. Chemical modification of pork liver enzyme did not alter the immunological integrity of the molecule even when polymerisation of the enzyme was induced. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index