Effect of haemodialysate and its peptide fractions on lactate dehydrogenase activity in erythrocytes from healthy subjects and patients with end-stage renal disease.

Autor: Smoleński, O., Tabarowski, Z., Miszta, H., Dąbrowski, Z.
Zdroj: International Urology & Nephrology; Nov1992, Vol. 24 Issue 6, p673-678, 6p
Abstrakt: The effect of haemodialysate and its 3 peptide fractions on lactate dehydrogenase activity in erythrocytes was studied in patients treated by repeated haemodialysis for end-stage renal disease and in healthy subjects. Erythrocytes from dialyzed patients showed significantly lower LDH activity than those from healthy subjects. After a 3-h incubation with haemodialysate (675 and 450 μg protein/ml) or its peptide fraction III (270 and 190 μg protein/ml), a significant inhibition of LDH activity was observed. On the other hand, neither haemodialysate nor its peptide fractions inhibited LDH activity in red blood cells from patients with end-stage renal disease treated by repeated haemodialysis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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