An evaluation of DNA polymerase α as a prognostic predictor in early breast cancers smaller than 2 cm.

Autor: Nishimura, Reiki, Nagao, Kazuharu, Miyayama, Haruhiko, Ishihara, Akira, Matsuda, Masakazu, Baba, Kenichirou, Matsuoka, Yukio, Yamashita, Hiroya, Fukuda, Makoto, Higuchi, Akihiro, Saiki, Takahito
Zdroj: Breast Cancer (13406868); Apr1995, Vol. 2 Issue 1, p45-50, 6p
Abstrakt: We examined the relationship between proliferative activity determined by DNA polymerase α and clinicopathologic variables in breast cancer patients, and evaluated the usefulness of DNA polymerase α as a prognostic predictor in 337 early breast cancers with tumors smaller than 2 cm, which had favorable outcomes. About 60% of tumors had lower proliferative activity. A significant correlation was found between DNA polymerase α and ER, PgR, histological type, or the degree of infiltration into lymphatic vessels which reflect the prognosis. Cancers with higher DNA polymerase α activity were associated with shorter disease-free and overall survival times. In a multivariate analysis the DNA polymerase α was found to be an independent and significant factor in early breast cancer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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