| Autor: |
Pietrek, J., Kokot, F., Kuska, J. |
| Zdroj: |
International Urology & Nephrology; Jun1978, Vol. 10 Issue 2, p153-160, 8p |
| Abstrakt: |
Six patients with chronic renal failure on regular dialysis treatment were given low doses (0.5-1.0 μg/day) of 1α-hydroxyvitamin D, monitoring the serum calcium, inorganic phosphate, immunoreactive parathyroid hormone concentration (IPTH) and alkaline phosphatase activity. The serum calcium rose in all patients after 7 days' treatment, in some subjects to hypercalcemic range; this effect persisted 6-14 days after withdrawal of 1α-hydroxyvitamin D. The elevated serum IPTH rose in the first days of treatment, but later decreased to normal values. It is suggested that active vitamin D metabolites are necessary for normal response of parathyroid glands to variation in serum calcium. Low-dose 1α-hydroxyvitamin D treatment appears to be a promising method of correcting hypocalcemia and secondary hyperparathyroidism in chronic renal failure. Careful control of serum calcium is necessary, as hypercalcemia may occur even after minute doses of 1α-hydroxyvitamin D. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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