| Autor: |
Yamamoto, Noritaka, Gotoh, Kohshi, Yagi, Yasuo, Terashima, Yasushi, Nagashima, Kenshi, Sawa, Toshiyuki, Deguchi, Fumiko, Nawada, Masumi, Tanaka, Haruhito, Tsukamoto, Tatsuo, Hirakawa, Senri |
| Zdroj: |
Annals of Nuclear Medicine; Jun1993, Vol. 7 Issue 2, p97-103, 7p |
| Abstrakt: |
In 41 patients with sarcoidosis (diagnosed according to criteria recommended by the Committee on Diffuse Pulmonary Disease, Ministry of Health and Welfare, Japan 1988), thallium-201 (Tl) myocardial SPECT was performed to investigate: (1) the ability ofTl SPECT to detect cardiac involvement of sarcoidosis with images recorded at rest and 2 hours later, and (2) the relationships betweenTl myocardial SPECT findings and the activity of sarcoidosis or endomyocardial biopsy findings. As to the abnormal findings inTl myocardial SPECT, (1) a low density area was seen in 13 of 41 cases (31.7%) and non-uniform uptake was found in 17 cases (41.5%), (2) the mean washout ratio (n=39) was 16.5±7.4%, which is significantly (p < 0.05) lower than that found in normal subjects, 23.9±7.5 % (n=10). Of the 19 patients judged visually to be normal, 5 patients had a reduced mean washout ratio less than 12%. Thus, the incidence of abnormal findings including all types of abnormality, onTl myocardial SPECT in sarcoidosis was 63.4% (26/41 cases). In studying the relationship betweenTl myocardial SPECT findings and the activity of sarcoidosis (as measured by the serum ACE (angiotensin converting enzyme) or lysozyme level, or the presence of more than 30% symphocyte fraction in BALF (broncho-alveolar lavage fluid)), 20 (80%) of 25 cases withTl abnormality were judged to be active sarcoidosis, while only 6 (37.5%) of 16 cases with normal findings onTl SPECT were judged to be active. This suggests that there is a significant (p < 0.01) relationship between the presence or absence of an abnormal finding onTl myocardial SPECT and the activity of sarcoidosis. Among 13 patients examined by endomyocardial biopsy, 10 patients had abnormal findings onTl myocardial SPECT and 7 of these 10 patients had no histological evidence of cardiac sarcoidosis. In all of these 7 patients, however, sarcoidosis was judged to be active. This suggest that endomyocardial biopsy is of limited value in the diagnosis of cardiac sarcoidosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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