| Autor: |
Chung-Li Ho, I-Hsiang Liu, Yu-Hsien Wu, Liang-Cheng Chen, Chun-Lin Chen, Wan-Chi Lee, Cheng-Hui Chuang, Te-Wei Lee, Wuu-Jyh Lin, Lie-Hang Shen, Chih-Hsien Chang |
| Zdroj: |
Journal of Biomedicine & Biotechnology; 2011, p1-8, 8p |
| Abstrakt: |
Molecular imaging with promise of personalized medicine can provide patient-specific information noninvasively, thus enabling treatment to be tailored to the specific biological attributes of both the disease and the patient. This study was to investigate the characterization of DO3A-CH2CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH2 (AMBA) in vitro, MicroSPECT/CT imaging, and biological activities of 111In-AMBA in PC-3 prostate tumor-bearing SCID mice. The uptake of 111In-AMBA reached highest with 3.87 ± 0.65% ID/g at 8 h. MicroSPECT/CT imaging studies suggested that the uptake of 111In-AMBA was clearly visualized between 8 and 48 h postinjection. The distribution half-life (t1/2a) and the elimination half-life (t1/2β) of 111In-AMBA in mice were 1.53 h and 30.7 h, respectively. The Cmax and AUC of 111In-AMBA were 7.57% ID/g and 66.39 h*%ID/g, respectively. The effective dose appeared to be 0.11mSv/MBq-1. We demonstrated a good uptake of 111In-AMBA in the GRPR-overexpressed PC-3 tumorbearing SCID mice. 111In-AMBA is a safe, potential molecular image-guided diagnostic agent for human GRPR-positive tumors, ranging fromsimple and straightforward biodistribution studies to improve the efficacy of combinedmodality anticancer therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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