Synergistic effect of K-18 and concomitant hyperthermia for treatment of lewis lung carcinoma in mice.

Autor: Tamada, Ryuichiro, Kai, Hideaki, Sugimachi, Keizo, Takenaka, Kenji, Hiramoto, Yoichiro, Inokuchi, Kiyoshi
Zdroj: Japanese Journal of Surgery; Mar1985, Vol. 15 Issue 2, p173-176, 4p
Abstrakt: We investigated the synergistic anti-tumor effects of K-18 (conjugate of human γ-globulin and melphalan) and concomitantly administered hyperthermia on Lewis lung carcinoma in mice. The antitumor effect of a subeffective dose of K-18 or an equivalent dose of melphalan alone was enhanced by local hyperthermia. K-18 administration demonstrated a greater potentiation for inhibition of tumor growth than that of melphalan alone. Local hyperthermia plus K-18 reduced the dose of melphalan required for tumor growth inhibition by melphalan alone. The combined application of K-18 and hyperthermia for treating cancer warrants further study. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: