| Autor: |
Edwards, Michael, Gordon, Deborah, Salamy, Alan, Levin, Victor, Phillips, Theodore |
| Zdroj: |
Journal of Neuro-Oncology; Jun1984, Vol. 2 Issue 2, p95-98, 4p |
| Abstrakt: |
Rats pretreated for 5 days with 50 mg/ kg of pentobarbital tolerated statistically significant higher doses of misonidazole before the onset of misonidazole-induced neurotoxicity than rats treated intermittently with the same dose of pentobarbital. Presumably in pretreated rats, pentobarbital induced an increase in the activities of hepatic microsomal enzymes that led to a more rapid metabolism of misonidazole than in rats treated only intermittently. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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